A capacity crowd is expected as Mourinho brings his Premier League title contenders to take on the Eagles.
All stations close to the stadium will be open as normal today but there are no Southern train serves to or from London Bridge.
On the road Spring Lane bridge is still closed as road works take place so traffic could build up before the game.
Turnstiles at the ground open from 1.30pm. Crystals will be open at 12pm and the other bars around the ground will be open at 12.30pm.
For more information go to cpfc.co.uk.