£3.2m is set to be spent to improve London Road.
Some works have already taken place in the past three years, but there is more work to be done.
Almost £600,000 will be spent helping 40 businesses to clean and repaint, create new shop fronts, signs, awnings and security shutters, and restoring historic features such as pilasters.
Work will start in Broad Green this month and is expected to finish by West Croydon station next spring.
Owners and occupiers of the premises selected for improvements will receive 90 per cent funding towards the costs and will be expected to find the other 10 per cent.
Pavements will be widened and repaved and there will be new benches and parking places for bicycles.
The street improvements will begin by West Croydon station towards the end of this month and finish by the Broad Green end by next summer.
The cabinet member for economic development Councillor Toni Letts said: “If we create inviting public spaces where people feel safe to shop and spend their leisure time we will change Croydon's image and bring in even more much-needed investment.”
The project is part of the Connected Croydon programme which will see more than £50m spent on borough improvements.