Harlequins centre George Lowe will make his 100th appearance for the club when they take on Munster at The Stoop in the Heineken Cup quarter-final.

There are four changes to the team that played Gloucester last Friday.

Among the backs, Tom Williams and Ugo Monye return to start on the wings, with Mike Brown continuing at full-back, while Lowe partners Tom Casson in the centre.

In the forwards, the front five remain unchanged, while Maurie Fa’asavalu and captain Chris Robshaw return to the flanks.

Tom Guest has recovered from illness and is named among the replacements.

This fixture will be the biggest that the Twickenham Stoop has ever held.

With a 15,000 capacity crowd attending, Harlequins are encouraging supporters from both teams to arrive with plenty of time.

Gates will open at 12pm for the 2pm kick-off (live on Sky Sports 2).