Uncapped forwards Mako Vunipola and Tom Youngs have been called into the England squad for the QBE autumn internationals.
England coach Stuart Lancaster has made four injury-enforced changes to the elite squad he originally named in July for the Tests against Fiji, Australia, South Africa and New Zealand.
Saracens prop Vunipola, whose father played at two World Cups for Tonga, and Leicester hooker Youngs are covering for Alex Corbisiero and Rob Webber.
Harlequins wing Ugo Monye has also been promoted to fill the back-three berth left vacant when Ben Foden damaged ankle ligaments playing for Northampton.
James Haskell, who returned to the England team for the drawn third Test against South Africa in Port Elizabeth on the summer tour, has been promoted from the Saxons to replace Tom Croft.
Lancaster had already made one change to the original squad, replacing retired prop Matt Stevens with Bath's David Wilson.
Vunipola was drafted into the Saxons as Wilson's replacement but the 21-year-old has now been fast-tracked into the senior squad after an impressive start to the season with Saracens.
Youngs, the elder brother of scrum-half Ben Youngs, has only established his place in the Leicester team this season after being converted from a hard-running centre.
The 25-year-old toured South Africa with England in the summer and he will be Dylan Hartley's understudy for the autumn Tests, following Lee Mears' international retirement.
Monye, who won his last England cap against Scotland in 2010, has returned to form with a bang this season, scoring four tries in five Premiership games for Harlequins.